Clenbuterol’s Characteristics and Attributes
Clenbuterol isn’t an anabolic steroid, but rather a stimulant belonging to a class of compounds known as sympathomimetic. This classification contains other similar compounds an average individual might be more familiar with, such as: ephedrine, amphetamines, cocaine, caffeine, albuterol, and many others. This drug category is quite broad with each compound in the family being related, having many similarities and operating in a same manner through similar pathways. The effect of Clenbuterol on the nervous system involves an interaction with adrenoreceptors, located in different tissues and cell types in the body. The resulting effect of Clenbuterol binding with adrenoreceptors in different tissues varies with the type of tissue or depends on the type of tissues being stimulated. Our major concern in particular is the effect of Clenbuterol on adipose (fat) tissue.
There exist two different types of adrenoreceptors in the body known as “Alpha” and “Beta” receptors and within these two receptors there are 9 subtypes. Examples are alpha-1, alpha 2, beta-1, beta-2 receptors etc. The difference between Clenbuterol and other stimulant compounds in its family lies in their ability to stimulate different subtypes, focus on a particular subtype or multiple subtypes. Clenbuterol in particular is better known for its strong and exclusive stimulation of the beta-2 adrenoreceptors, and therefore commonly referred to as a beta-2 receptor agonist. Within fat tissues (adipose), beta-2 receptors stimulated by Clenbuterol results in lipolysis, which is the breakdown of fat into free fatty-acids. Over the years Clenbuterol has gained popularity amongst bodybuilders, athletes, entertainment celebrities and people looking to shed a few pounds of fat.
Clenbuterol was originally (and still is) used as a medicine in the prescription drug market. It is used as a bronchodilator in the treatment of asthma. It is also frequently administered in asthma inhalers as the primary active drug of the inhaler. The use of Clenbuterol as a medication for asthma is primarily a European medical practice while in North America, Clenbuterol’s sister compound “Albuterol”, is utilized instead. The activation of beta-2 receptors in the cell-lining of the bronchial tubes initiates the opening and expansion of the airways (bronchial dilation) in the nose, throat and lungs. Many sympathomimetic stimulants exert this effect, however Clenbuterol and Albuterol are more effective in particular for this purpose. Clenbuterol is also used in the treatment of other medical conditions, such as cardiovascular shock, heart arrhythmias, hypertension, allergic reactions and swelling, migraine headaches, anaphylactic shock and histamine reactions.
Even though Clenbuterol is a beta-2 receptor agonist, it exhibits effects on different receptor subtypes with emphasis on the beta-2 subtype. When comparing Ephedrine to other stimulants, they are better known for stimulating multiple alpha and beta receptors by an equal degree rather than stimulating a receptor subtype by a large degree. According to many in the body-building community, Clenbuterol is anabolic in muscle tissue. However, Clenbuterol is only slightly anabolic in muscle tissue and this has been found to be the case in animals rather than humans (which requires a long period of usage before the effects rise to a significant measurable level).
An interesting point to note is that through consistent usage, Clenbuterol downregulates beta-2 receptors in response to its stimulation of these receptors in the body, and it occurs quickly. The result of this effect is diminished the fat loss during usage until the fat loss completely stops. There are two methods used as a remedy to this effect. The first is the introduction of time-off in the usage of these drugs (minimum of 2 weeks). Second is the use of an anti-histamine drug “Ketotifen Fumarate” that is known for the upregulation of beta-2 receptors. There are rumors of Benadryl having the same effects as Ketotifen Fumarate on beta-2 receptors, however, this was found to be untrue because even though Benadryl is an anti-histamine like Ketotifen Fumarate, it operates on a different pathway.
Clenbuterol’s Side Effects
Since Clenbuterol is not an anabolic steroid, it doesn’t exhibit or express any of the known side-effects that are associated with an anabolic steroid. Instead, Clenbuterol expresses side-effects that are common with drugs and compounds of the stimulant class. Meaning that many Clenbuterol side-effects are similar to that of Ephedrine, Caffeine and other stimulants to varying degrees. Clenbuterol side-effects include those that are considered somehow unique to the compounds that are unseen with other stimulants.
Perhaps the most unique side-effect of Clenbuterol is the commonly reported muscle cramping side-effect. It is also a reported side-effect of Clenbuterol’s close sister compound, Albuterol. This results from Clenbuterol’s depletion of Taurine in the body. Studies have shown that the use of Clenbuterol depletes the level of amino-acid Taurine both in muscle tissue and serum blood plasma. Taurine, alongside Sodium, Magnesium and Potassium play crucial roles in the regulation of bio-electrical nerve impulse and signals that govern contraction and relaxation of all types of muscle tissue. The depletion of Taurine results in intense, involuntary and painful muscle contractions that leads to cramps. Studies have shown that supplementing with Taurine at 2.5 – 5 grams each day can reduce this side-effect.
As a stimulant, Clenbuterol is actually harsh on cardiac tissue and the cardio-vascular system, although there is some evidence that Clenbuterol promotes cardiac recovery and muscle growth in patients with chronic heart-failure using high dosage. Nonetheless, the peak Clenbuterol dosage used in the study is considered extreme and is not to be attempted by anyone due to its high-risk nature. Also, Myocardial Ischemia is a reported risk of Clenbuterol usage, a condition whereby there is insufficient supply of blood to the heart resulting from arterial vasoconstriction caused by Clenbuterol. A study on rats revealed Clenbuterol’s alarming myotoxic effects, where it caused the death of Soleus muscle as well as the heart muscle. Nevertheless, the dosage in this study is considered extreme, yet it’s a concern surrounding the use of Clenbuterol. Concerning the heart and cardiovascular system with Clenbuterol, a vast majority of these negative effects involves enlargement of the ventricles, cardiac necrosis and cardiac hypertrophy. There’s no doubt, that Clenbuterol places a great degree of strain on the cardio-vascular system and this should be a considered by all potential users.
Other common Clenbuterol side-effects include insomnia, tremors (“shaky hands”), increased blood pressure, sweating and perspiration, headaches and nausea. Side-effects of Clenbuterol may include adverse allergies and reactions such as rashes and hives.
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Clenbuterol Cycles and Uses
Clenbuterol is commonly utilized in cutting, pre-contest, and fat loss cycles. It is rarely utilized during the bulking phase or off-season. A small fraction of Clenbuterol users might prefer to use it during the bulking phase in a vain attempt to stave-off fat gain during a bulking period where the consumption of caloric is higher than usual and above basal metabolic levels. Nevertheless, those who propose to do this are essentially wasting time and money, as the mechanics of Clenbuterol doesn’t provide for this effect. As explained earlier, Clenbuterol is responsible for binding with receptors on fat (adipose) tissue and initiating lipolysis, which is the process of releasing into the bloodstream triglycerides stored in fat cells as free fatty-acids. These free fatty-acid circulate around the bloodstream through the body, and undergo the second stage of fat loss: fatty acid oxidation. Meaning the fatty-acids must be shuttled into cells and the mitochondria to be “burned” off, which will not occur in any significant amount if the consumption of caloric is too high.
Clenbuterol cycles can be run solitarily with no other compounds or stacked with other compounds. Whether or not it is run solitarily doesn’t change the manner in which Clenbuterol cycles are run. Which means that Clenbuterols are either used in the 2 weeks-on / 2 weeks-off protocol, or for 8 continued weeks with the use of Ketotifen Fumarate every second week. Also, it’s recommended that Clenbuterol shouldn’t be utilized for more than a 12-week period so as to ensure that the body’s cardio-vascular and other systems receive appropriate rest from the compound.
Clenbuterol Dosages and Administration
Being an asthma medication for the treatment of asthma, Clenbuterol dosage is in the range of 20 – 40 mcg per day.
To achieve any significant amount of fat loss, the maximum Clenbuterol dosage that users can titrate up to is 120 – 160 mcg per day. Females may tolerate less, in the range of 80 – 100 mcg per day.
Regardless of the user being male or female, Clenbuterol dosage must be slowly tit-rated to the maximum dosage mentioned. Which means that an initial starting dosage would be 40 mcg of Clenbuterol for the first 3 days, and on the 4th day of the period, the dosage is increased by another 20 mcg (having a total of 60 mcg per day), and 3 days following it is topped again and so on and so forth. Some users can tolerate quick titration upwards, while others may require a slow steady increase.
Titration downwards may not be necessary when ending the use of Clenbuterol, though some have a personal preference for it.
Clenbuterol has a half-life of approximately 37-hours, so all dosage of Clenbuterol should ideally be consumed at once in the morning. Spreading Clenbuterol dosage throughout the day is not required and may lead to a severe case of insomnia and sleep disturbances.
How to Buy Clenbuterol
Clenbuterol is one of the most common / popular fat loss agents in existence and is one of the easiest compounds to buy on the black market or even legally as a research chemical.
Pharmaceutical grade Clenbuterol ranges from $0.4 – $1 per tablet which depends on the pharmaceutical product purchased. Nearly all pharmaceutical grade Clenbuterol tablets are supplied in 20 mcg tablets. It isn’t uncommon to see black market products dosed at 40 mcg, 50 mcg, and even 100 mcg tablets with prices between $0.4 – $2 per tablet.
Research grade products produced by research chemical companies are mostly in liquid form supplied with a dropper, spray pump (with each spray measuring 20 mcg per spray approximately). The concentration of Clenbuterol solutions in these liquid products is commonly 200 mcg per ml in a 30-ml bottle, with the price ranging between $40 – $80 per bottle (depending on the company purchased from).
As a result of laws in the United States, Clenbuterol can be bought widely for research purposes, but is mostly listed as “not for human consumption”.
Nowadays, there are newer, safer products on the market, aiming at the same results, being 100% legal. Modern research has enabled the creation of a new generation of products, which allow for greater, longer dosage WITHOUT the side effects:
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